Intraoperative frozen section (IFS) is one of the most commonly used methods for intraoperative assessment of SLN. This limits the use of ALND only to patients with metastatic sentinel lymph nodes (SLN) (Cipolla et al., 2010 Lucci et al. SLNB has a lower incidence of complications, especially lymphedema, than axillary lymph node dissection (ALND). Lymph node evaluation is essential because axillary lymph nodes’ status affects survival and the cancer recurrence rate more than any other factor (Fisher et al. The sentinel lymph node biopsy (SLNB) technique is routinely used for nodal staging of breast cancer when nodal metastasis is not manifested clinically. Due to recently developed screening programs and elevated public awareness of breast cancer, the early detection rate has increased therefore, axillary metastases’ incidence rates are continuously decreasing (Berry et al. In 2020, more than 680,000 died from breast cancer worldwide (Sung et al. Recently cancer statistics stated that breast cancer has the highest incidence among all cancers in women. However, the sensitivity is low for micro-metastasis. The intraoperative frozen section of SLN has good sensitivity for diagnosing breast cancer macro-metastasis. The overall diagnostic odds ratio of IFS for diagnosing SLN metastasis was 569.5 95% CI, P < 0.001. The overall positive likelihood ratio was 121.4 95% CI, P < 0.001, and the overall negative likelihood ratio was 0.226 95% CI, P < 0.001. The overall sensitivity of IFS for SLN metastasis was 74.7% 95% CI, P < 0.001. This meta-analysis pooled the results of 110 studies. The analyses were conducted using the Open Meta-analyst software. The statistical analysis included the sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and pooled studies’ diagnostic odds ratio outcomes. Data were collected by searching PubMed, Cochrane, Scopus, and Web of Science electronic databases for trials matching our eligibility criteria. This meta-analysis aims to provide evidence about the diagnostic accuracy and the applicability of IFS of SLN in breast cancer patients. The intraoperative frozen section (IFS) of SLN is used for lymph node assessment.
#SENTINEL NODE BIOPSY FROZEN SECTION FREE#
Sentinel lymph node (SLN) sampling is important for evaluating the nodal stage of breast cancer when the axillary nodes are clinically free of metastasis.
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